Effect of food on the absorption of vigabatrin

1. This study, involving eight healthy volunteers, revealed that food intake does not have a clinically significant effect on vigabatrin kinetics. 2. Kinetics of vigabatrin in the fasting state showed low inter‐individual variation. 3. The plasma concentration vs time profile followed a bi‐exponenti...

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Bibliographic Details
Published in:British journal of clinical pharmacology 1989-01, Vol.27 (S1), p.23S-25S
Main Authors: Frisk‐Holmberg, M, Kerth, P, Meyer, P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aminocaproates - adverse effects
Aminocaproates - pharmacokinetics
Anticonvulsants - adverse effects
Anticonvulsants - pharmacokinetics
Biological Availability
Food
Humans
Intestinal Absorption
Male
Random Allocation
Vigabatrin
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Summary:1. This study, involving eight healthy volunteers, revealed that food intake does not have a clinically significant effect on vigabatrin kinetics. 2. Kinetics of vigabatrin in the fasting state showed low inter‐individual variation. 3. The plasma concentration vs time profile followed a bi‐exponential decline with a terminal half‐life of 6.8 h and a relative bioavailability of 92% +/‐ 11%. 4. In the clinical setting, vigabatrin may be taken at times convenient for the patient.
ISSN:0306-5251
1365-2125
DOI:10.1111/j.1365-2125.1989.tb03457.x