Absence of Linkage of Phonological Coding Dyslexia to Chromosome 6p23-p21.3 in a Large Family Data Set

Previous studies have suggested that a locus predisposing to specific reading disability (dyslexia) resides on chromosome 6p23-p21.3. We investigated 79 families having at least two siblings affected with phonological coding dyslexia, the most common form of reading disability (617 people genotyped,...

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Bibliographic Details
Published in:American journal of human genetics 1998-11, Vol.63 (5), p.1448-1456
Main Authors: Field, L.L., Kaplan, B.J.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
African Continental Ancestry Group - genetics
Alberta
Alleles
Auditory Perception
Biological and medical sciences
Child
Chromosome 6
Chromosome Mapping
Chromosomes, Human, Pair 6
Dyslexia
Dyslexia - genetics
Dyslexia - physiopathology
Europe - ethnology
European Continental Ancestry Group - genetics
Gene Frequency
Genetic Linkage
Genetic Markers
Genetics
Genotype
HLA
Humans
Language and communication disorders
Lod Score
Medical sciences
Nuclear Family
Phonological coding
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
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Summary:Previous studies have suggested that a locus predisposing to specific reading disability (dyslexia) resides on chromosome 6p23-p21.3. We investigated 79 families having at least two siblings affected with phonological coding dyslexia, the most common form of reading disability (617 people genotyped, 294 affected), and we tested for linkage with the genetic markers reported to be linked to dyslexia in those studies. No evidence for linkage was found by LOD score analysis or affected-sib-pair methods. However, using the affected-pedigree-member (APM) method, we detected significant evidence for linkage and/or association with some markers when we used published allele frequencies with weighting of rarer alleles. APM results were not significant when we used marker allele frequencies estimated from parents. Furthermore, results were not significant with the more robust SIMIBD method using either published or parental marker frequencies. Finally, family-based association analysis using the AFBAC program showed no evidence for association with any marker. We conclude that the APM method should be used only with extreme caution, because it appears to have generated false-positive results. In summary, using a large data set with high power to detect linkage, we were unable to find evidence for linkage or association between phonological coding dyslexia and chromosome 6p markers.
ISSN:0002-9297
1537-6605
DOI:10.1086/302107