Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorder

The relationship between orbitofrontal cortex (OFC) volumes and functional domains in treatment-resistant patients with schizophrenia or schizoaffective disorder is poorly understood. OFC dysfunction is implicated in several of the behaviors that are abnormal in schizophrenia. However, little is kno...

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Bibliographic Details
Published in:Psychiatry research 2005-11, Vol.140 (2), p.133-145
Main Authors: Hoptman, Matthew J., Volavka, Jan, Weiss, Elisabeth M., Czobor, Pál, Szeszko, Philip R., Gerig, Guido, Chakos, Miranda, Blocher, Joseph, Citrome, Leslie L., Lindenmayer, Jean-Pierre, Sheitman, Brian, Lieberman, Jeffrey A., Bilder, Robert M.
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Aggression
Basal Ganglia Diseases - diagnosis
Basal Ganglia Diseases - epidemiology
Basal Ganglia Diseases - physiopathology
Biological and medical sciences
Chronic Disease
Cognition Disorders - diagnosis
Cognition Disorders - epidemiology
Female
Functional Laterality - physiology
Humans
Magnetic Resonance Imaging - statistics & numerical data
Male
Medical sciences
Neuropsychological function
Neuropsychological Tests
Orbitofrontal cortex
Positron-Emission Tomography
Prefrontal Cortex - metabolism
Prefrontal Cortex - physiopathology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Psychotic Disorders - diagnostic imaging
Psychotic Disorders - epidemiology
Psychotic Disorders - physiopathology
Schizophrenia
Schizophrenia - diagnostic imaging
Schizophrenia - epidemiology
Schizophrenia - physiopathology
Surveys and Questionnaires
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Summary:The relationship between orbitofrontal cortex (OFC) volumes and functional domains in treatment-resistant patients with schizophrenia or schizoaffective disorder is poorly understood. OFC dysfunction is implicated in several of the behaviors that are abnormal in schizophrenia. However, little is known about the relationship between these behaviors and OFC volumes. Forty-nine patients received magnetic resonance imaging scanning as part of a double-blind treatment study in which psychiatric symptomatology, neuropsychological function, and aggression were measured. OFC volumes were manually traced on anatomical images. Psychiatric symptomatology was measured with the Positive and Negative Syndrome Scale (PANSS). Aggression was measured with the Overt Aggression Scale (OAS) and with the PANSS. Neuropsychological function was assessed using a comprehensive test battery. Larger right OFC volumes were associated with poorer neuropsychological function. Larger left OFC gray matter volumes and larger OFC white matter volumes bilaterally were associated with greater levels of aggression. These findings are discussed in the context of potential iatrogenic effects.
ISSN:0925-4927
0165-1781
1872-7506
1872-7123
DOI:10.1016/j.pscychresns.2005.07.004