Gastrointestinal motility and glycemic control in diabetes: the chicken and the egg revisited?

Upper gastrointestinal dysfunction occurs frequently in diabetes and potentially contributes to both abdominal symptoms and impaired glycemic control; conversely, variations in blood glucose concentration reversibly affect gut motility in humans. In this issue of the JCI, Anitha et al. report apopto...

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Bibliographic Details
Published in:	The Journal of clinical investigation 2006-02, Vol.116 (2), p.299-302
Main Authors:	Rayner, Christopher K, Horowitz, Michael
Format:	Article
Language:	eng
Subjects:	Animals Biomedical research Blood Glucose - metabolism Diabetes Complications Diabetes Mellitus - physiopathology Gastrointestinal Diseases - etiology Gastrointestinal Diseases - physiopathology Gastrointestinal Motility - physiology Humans Phosphatidylinositol 3-Kinases - metabolism
Online Access:	Get full text
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Summary:	Upper gastrointestinal dysfunction occurs frequently in diabetes and potentially contributes to both abdominal symptoms and impaired glycemic control; conversely, variations in blood glucose concentration reversibly affect gut motility in humans. In this issue of the JCI, Anitha et al. report apoptosis of rodent enteric neurons under hyperglycemic conditions, both in vitro and in vivo, associated with impaired PI3K activity and preventable by glial cell line-derived neurotrophic factor. These observations add to recent insights gained from animal models regarding the etiology of diabetic gastrointestinal dysfunction, but investigators must strive to translate animal data to human diabetes.
ISSN:	0021-9738 1558-8238