Whole-Genome Screening in Ankylosing Spondylitis: Evidence of Non-MHC Genetic-Susceptibility Loci

Ankylosing spondylitis (AS) is a common inflammatory arthritis predominantly affecting the axial skeleton. Susceptibility to the disease is thought to be oligogenic. To identify the genes involved, we have performed a genomewide scan in 185 families containing 255 affected sibling pairs. Two-point a...

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Bibliographic Details

Published in:	American journal of human genetics 2001-04, Vol.68 (4), p.918-926
Main Authors:	Laval, S.H., Timms, A., Edwards, S., Bradbury, L., Brophy, S., Milicic, A., Rubin, L., Siminovitch, K.A., Weeks, D.E., Calin, A., Wordsworth, B.P., Brown, M.A.
Format:	Article
Language:	eng
Subjects:	ankylosing spondylitis Biological and medical sciences Chromosome 1 chromosome 10 chromosome 16 chromosome 19 chromosome 2 chromosome 6 chromosome 9 Chromosome Mapping Chromosomes, Human - genetics Cohort Studies Diseases of the osteoarticular system Female Genetic Predisposition to Disease - genetics Genetic Testing Genome, Human Genotype Humans Inflammatory joint diseases Lod Score Major Histocompatibility Complex - genetics Male Matched-Pair Analysis Medical sciences Nuclear Family Software Spondylitis, Ankylosing - genetics Statistics, Nonparametric
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