Common Variants in the 5′ Region of the Leptin Gene Are Associated with Body Mass Index in Men from the National Heart, Lung, and Blood Institute Family Heart Study

Linkage of body mass index (BMI) to a broad region of chromosome 7q22-35 has been reported in multiple studies. We previously published a multipoint LOD score of 4.9 at D7S1804 for BMI from the National Heart, Lung, and Blood Institute Family Heart Study. Leptin ( LEP), the human homolog of the mous...

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Bibliographic Details
Published in:American journal of human genetics 2004-08, Vol.75 (2), p.220-230
Main Authors: Jiang, Y., Wilk, J.B., Borecki, I., Williamson, S., DeStefano, A.L., Xu, G., Liu, J., Ellison, R.C., Province, M., Myers, R.H.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Body Mass Index
General aspects. Genetic counseling
Genetic Markers
Genotype
Haplotypes
Humans
Leptin - genetics
Male
Medical genetics
Medical sciences
Middle Aged
Phenotype
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Summary:Linkage of body mass index (BMI) to a broad region of chromosome 7q22-35 has been reported in multiple studies. We previously published a multipoint LOD score of 4.9 at D7S1804 for BMI from the National Heart, Lung, and Blood Institute Family Heart Study. Leptin ( LEP), the human homolog of the mouse obesity ( ob) gene, is positioned near the linkage peak and is the most prominent candidate gene in this region. Interest in LEP as a susceptibility gene for human obesity has led to numerous linkage and association studies, but the results of these studies are still controversial. In the present study, we employed family-based tests of association with both a quantitative measure of BMI adjusted for age and sex and a dichotomously defined obesity trait. We genotyped 29 single-nucleotide polymorphisms (SNPs) spanning 240 kb around the LEP gene in the 82 extended pedigrees with the strongest evidence for linkage. When the programs TRANSMIT and FBAT were used, a number of SNPs showed association in men but not women, for both the quantitative and qualitative trait definitions ( P
ISSN:0002-9297
1537-6605
DOI:10.1086/422699