Deletion analysis of the tumorous-head (tuh-3) gene in Drosophila melanogaster

In the presence of the naturally occurring maternal-effect alleles tuh-1h or tuh-1g, the tuh-3 mutant gene can cause the tumorous-head trait or the sac-testis trait. The tuh-3 gene functions as a semidominant in the presence of the tuh-1h maternal effect. Eye-antennal structures are replaced by post...

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Bibliographic Details
Published in:Genetics (Austin) 1981-09, Vol.99 (1), p.99-107
Main Authors: Kuhn, D.T, Woods, D.F, Andrew, D.J
Format: Article
Language:English
Subjects:
Alleles
animal breeding
animal genetics
Animals
arthropods
Chromosome Mapping
Crosses, Genetic
Drosophila melanogaster - genetics
entomology
Extrachromosomal Inheritance
Female
Genes
Head and Neck Neoplasms - genetics
Investigations
Male
Phenotype
Recombination, Genetic
Citations: Items that cite this one
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Summary:In the presence of the naturally occurring maternal-effect alleles tuh-1h or tuh-1g, the tuh-3 mutant gene can cause the tumorous-head trait or the sac-testis trait. The tuh-3 gene functions as a semidominant in the presence of the tuh-1h maternal effect. Eye-antennal structures are replaced by posterior abdominal tergites and genital structures. If tuh-1h is replaced by its naturally occurring allele tuh-1g, tuh-3 functions as a recessive hypomorph and the defect switches from anterior to posterior structures, with a male genital-disc defect appearing with variable penetrance. Function and regulation of tuh-3+ may better be understood in light of the cytological localization of tuh-3 either adjacent to or as part of the bithorax complex. The tuh-3+ gene product appears to be essential for normal development, at least in the posterior end of the embryo.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/99.1.99