Caenorhabditis elegans Mutants Resistant to Inhibitors of Acetylcholinesterase

We characterized 18 genes from Caenorhabditis elegans that, when mutated, confer recessive resistance to inhibitors of acetylcholinesterase. These include previously described genes as well as newly identified genes; they encode essential as well as nonessential functions. In the absence of acetylch...

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Bibliographic Details
Published in:Genetics (Austin) 1995-06, Vol.140 (2), p.527-535
Main Authors: Nguyen, M, Alfonso, A, Johnson, C. D, Rand, J. B
Format: Article
Language:English
Subjects:
Acetylcholine - metabolism
Aldicarb - pharmacology
Animals
Caenorhabditis elegans
Caenorhabditis elegans - drug effects
Caenorhabditis elegans - genetics
Cholinesterase Inhibitors - pharmacology
Drug Resistance
Genes
Genes, Recessive
Genetics
Investigations
Mutation
Recombination, Genetic
Trichlorfon - pharmacology
Worms
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Summary:We characterized 18 genes from Caenorhabditis elegans that, when mutated, confer recessive resistance to inhibitors of acetylcholinesterase. These include previously described genes as well as newly identified genes; they encode essential as well as nonessential functions. In the absence of acetylcholinesterase inhibitors, the different mutants display a wide range of behavioral deficits, from mild uncoordination to almost complete paralysis. Measurements of acetylcholine levels in these mutants suggest that some of the genes are involved in presynaptic functions.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/140.2.527