Interaction of the yeast omnipotent suppressors SUP1(SUP45) and SUP2(SUP35) with non-mendelian factors

The SUP1 and SUP2 genes code for protein factors intimately involved in the control of translational accuracy. The disrupted alleles of these genes confer a recessive lethal phenotype in both [psi+] and [psi-] genetic backgrounds, indicating an essential function for the corresponding proteins. In [...

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Bibliographic Details
Published in:Genetics (Austin) 1991-07, Vol.128 (3), p.513-520
Main Authors: Dagkesamanskaya, A.R. (USSR Cardiology Research Center, Moscow, USSR), Ter-Avanesyan, M.D
Format: Article
Language:English
Subjects:
Alleles
Biological and medical sciences
Blotting, Southern
Classical genetics, quantitative genetics, hybrids
ESPORULACION
FENOTIPOS
Fundamental and applied biological sciences. Psychology
GENE
GENE RECESSIF
GENES
GENES RECESIVOS
Genes, Dominant - genetics
Genes, Lethal - genetics
Genes, Recessive - genetics
Genes, Suppressor - genetics
GENETICA
Genetics of eukaryotes. Biological and molecular evolution
GENETIQUE
Guanidine
Guanidines - pharmacology
INDICE DE CRECIMIENTO
Investigations
MUTACION INDUCIDA
Mutation - genetics
MUTATION PROVOQUEE
PHENOTYPE
Plasmids - genetics
Protein Biosynthesis - physiology
PROTEINAS VEGETALES
PROTEINE VEGETALE
SACCHAROMYCES CEREVISIAE
Saccharomyces cerevisiae - drug effects
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - growth & development
SPORULATION
TAUX DE CROISSANCE
Thallophyta, bryophyta
TRANSFORMACION GENETICA
TRANSFORMATION GENETIQUE
Vegetals
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Summary:The SUP1 and SUP2 genes code for protein factors intimately involved in the control of translational accuracy. The disrupted alleles of these genes confer a recessive lethal phenotype in both [psi+] and [psi-] genetic backgrounds, indicating an essential function for the corresponding proteins. In [psi+] diploids, heterozygous for the SUP1 null allele, several dominant phenotypes were evident with slow growth and inability to sporulate. These dominant phenotypes disappear after transformation with the multicopy plasmid carrying the wild-type allele of the SUP1 gene. Such dominant phenotypes were not observed for the SUP2 null allele. The incompatibility of multicopy plasmids carrying the SUP2 gene with guanidine hydrochloride-curable cytoplasmic factor(s) was also demonstrated. The possible mechanisms of interaction of the SUP1 and SUP2 genes with the [psi] determinant are discussed
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/128.3.513