Fish intake and risk of incident atrial fibrillation

Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is particularly common in the elderly. Although effects of fish intake, including potential antiarrhythmic effects, may favorably influence risk of AF, relationships between fish intake and AF incidence have not been eva...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2004-07, Vol.110 (4), p.368-373
Main Authors: Mozaffarian, Dariush, Psaty, Bruce M, Rimm, Eric B, Lemaitre, Rozenn N, Burke, Gregory L, Lyles, Mary F, Lefkowitz, David, Siscovick, David S
Format: Article
Language:English
Subjects:
Aged
Animals
Atrial Fibrillation - epidemiology
Cardiotonic Agents
Cohort Studies
Cooking
Diet
Dietary Fats
Fatty Acids, Omega-3
Fish Oils
Fishes
Follow-Up Studies
Humans
Incidence
Massachusetts - epidemiology
Proportional Hazards Models
Prospective Studies
Risk
Seafood
Tuna
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Summary:Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is particularly common in the elderly. Although effects of fish intake, including potential antiarrhythmic effects, may favorably influence risk of AF, relationships between fish intake and AF incidence have not been evaluated. In a prospective, population-based cohort of 4815 adults > or =age 65 years, usual dietary intake was assessed at baseline in 1989 and 1990. Consumption of tuna and other broiled or baked fish correlated with plasma phospholipid long-chain n-3 fatty acids, whereas consumption of fried fish or fish sandwiches (fish burgers) did not. AF incidence was prospectively ascertained on the basis of hospital discharge records and annual electrocardiograms. During 12 years' follow-up, 980 cases of incident AF were diagnosed. In multivariate analyses, consumption of tuna or other broiled or baked fish was inversely associated with incidence of AF, with 28% lower risk with intake 1 to 4 times per week (HR=0.72, 95% CI=0.58 to 0.91, P=0.005), and 31% lower risk with intake > or =5 times per week (HR=0.69, 95% CI=0.52 to 0.91, P=0.008), compared with
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.0000138154.00779.A5