Association between the Gene Encoding 5-Lipoxygenase–Activating Protein and Stroke Replicated in a Scottish Population

Cardiovascular diseases, including myocardial infarction (MI) and stroke, most often occur on the background of atherosclerosis, a condition attributed to the interactions between multiple genetic and environmental risk factors. We recently reported a linkage and association study of MI and stroke t...

Full description

Saved in:
Bibliographic Details
Published in:American journal of human genetics 2005-03, Vol.76 (3), p.505-509
Main Authors: Helgadottir, A., Gretarsdottir, S., St. Clair, D., Manolescu, A., Cheung, J., Thorleifsson, G., Pasdar, A., Grant, S.F.A., Whalley, L.J., Hakonarson, H., Thorsteinsdottir, U., Kong, A., Gulcher, J., Stefansson, K., MacLeod, M.J.
Format: Article
Language:English
Subjects:
5-Lipoxygenase-Activating Proteins
Aged
Biological and medical sciences
Cardiovascular disease
Carrier Proteins - genetics
Case-Control Studies
Female
Gene Frequency
General aspects. Genetic counseling
Genetic linkage
Genetic research
Genetic Variation
Genetics
Genotype
Haplotypes
Humans
Iceland
Male
Medical genetics
Medical sciences
Membrane Proteins - genetics
Middle Aged
Neurology
Polymorphism, Single Nucleotide
Risk Factors
Scotland
Stroke - genetics
Vascular diseases and vascular malformations of the nervous system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cardiovascular diseases, including myocardial infarction (MI) and stroke, most often occur on the background of atherosclerosis, a condition attributed to the interactions between multiple genetic and environmental risk factors. We recently reported a linkage and association study of MI and stroke that yielded a genetic variant, HapA, in the gene encoding 5-lipoxygenase–activating protein ( ALOX5AP), that associates with both diseases in Iceland. We also described another ALOX5AP variant, HapB, that associates with MI in England. To further assess the contribution of the ALOX5AP variants to cardiovascular diseases in a population outside Iceland, we genotyped seven single-nucleotide polymorphisms that define both HapA and HapB from 450 patients with ischemic stroke and 710 controls from Aberdeenshire, Scotland. The Icelandic at-risk haplotype, HapA, had significantly greater frequency in Scottish patients than in controls. The carrier frequency in patients and controls was 33.4% and 26.4%, respectively, which resulted in a relative risk of 1.36, under the assumption of a multiplicative model ( P=.007 ). We did not detect association between HapB and ischemic stroke in the Scottish cohort. However, we observed that HapB was overrepresented in male patients. This replication of haplotype association with stroke in a population outside Iceland further supports a role for ALOX5AP in cardiovascular diseases.
ISSN:0002-9297
1537-6605
DOI:10.1086/428066