The Interleukin 1 Gene Cluster Contains a Major Susceptibility Locus for Ankylosing Spondylitis
Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient to explain the pattern of familial recurrence of the disease. We have previously demonstrated suggesti...
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Published in: | American journal of human genetics 2004-10, Vol.75 (4), p.587-595 |
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Main Authors: | , , , , , , , , , , , , , |
Format: | Article |
Language: | eng |
Subjects: | |
Online Access: | Get full text |
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Summary: | Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy. Although the gene
HLA-B27 is almost essential for the inheritance of the condition, it alone is not sufficient to explain the pattern of familial recurrence of the disease. We have previously demonstrated suggestive linkage of AS to chromosome 2q13, a region containing the interleukin 1 (IL-1) family gene cluster, which includes several strong candidates for involvement in the disease. In the current study, we describe strong association and transmission of IL-1 family gene cluster single-nucleotide polymorphisms and haplotypes with AS. |
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ISSN: | 0002-9297 1537-6605 |