Inositol 1,3,4,6-tetrakisphosphate mobilizes calcium in Xenopus oocytes with high potency

Injection of Ins(1,3,4,6)P4 into Xenopus oocytes evoked Ca2(+)-dependent membrane currents with a potency 5-10 times less than Ins(1,4,5)P3, whereas Ins(1,3,4)P3 and Ins(1,3,4,5,6)P5 were almost ineffective. Responses to Ins(1,3,4,6)P4 arose through liberation of intracellular Ca2+ and through entry...

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Bibliographic Details
Published in:Biochemical journal 1991-01, Vol.273 (2), p.317-321
Main Authors: IVORRA, I, GIGG, R, IRVINE, R. F, PARKER, I
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Caffeine - pharmacology
calcium
Calcium - metabolism
Cell physiology
Dose-Response Relationship, Drug
Evoked Potentials
Fundamental and applied biological sciences. Psychology
inositol 1,3,4,6-tetrakisphosphate
Inositol Phosphates - administration & dosage
Inositol Phosphates - pharmacology
Isomerism
membrane currents
Membrane Potentials - drug effects
Molecular and cellular biology
oocytes
Oocytes - drug effects
Oocytes - metabolism
Responses to growth factors, tumor promotors, other factors
Xenopus laevis
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Summary:Injection of Ins(1,3,4,6)P4 into Xenopus oocytes evoked Ca2(+)-dependent membrane currents with a potency 5-10 times less than Ins(1,4,5)P3, whereas Ins(1,3,4)P3 and Ins(1,3,4,5,6)P5 were almost ineffective. Responses to Ins(1,3,4,6)P4 arose through liberation of intracellular Ca2+ and through entry of extracellular Ca2+. These results, together with the observation that Ins(1,3,4,6)P4 facilitated responses to Ins(1,4,5)P3, suggests that both of these compounds may act on the same intracellular receptors.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj2730317