Thiyl and phenoxyl free radicals and NADH. Direct observation of one-electron oxidation

Absolute rate constants for the reaction of NADH with thiyl free radicals derived from various sulphur-containing compounds of biological significance were measured by using the technique of pulse radiolysis. These and related reactions with phenoxyl free radicals are believed to occur through one-e...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical journal 1986-12, Vol.240 (3), p.897-903
Main Authors: Forni, L G, Willson, R L
Format: Article
Language:English
Subjects:
Electron Transport
Free Radicals
Kinetics
NAD
Oxidation-Reduction
Phenols
Pulse Radiolysis
Sulfhydryl Compounds
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Absolute rate constants for the reaction of NADH with thiyl free radicals derived from various sulphur-containing compounds of biological significance were measured by using the technique of pulse radiolysis. These and related reactions with phenoxyl free radicals are believed to occur through one-electron-transfer processes. Further evidence comes from studies with deuterated NADH. The results support the possibility that, in biochemical systems, thiols may act as catalysts linking hydrogen-atom and electron-transfer reactions.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj2400897