Comparison of Bone Graft Preparations to Treat a Critical Bone Defect on a Rodent Animal Model

Objective  Although autologous bone grafting is the most widely used treatment for bone defects, the most effective preparation remains unclear. This animal study aimed to compare different autologous bone grafting preparation for the treatment of rat́s calvaria critical bone defect. Methods  122 ra...

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Published in:Revista brasileira de ortopedia 2024-09, Vol.59 (4), p.e532-e541
Main Authors: Vieira, Rian Souza, Borges, Renan Ernesto Reis, Tiezzi, Daniel Guimarães, Shimano, Antonio Carlos, Zamarioli, Ariane, Defino, Helton Luiz Aparecido
Format: Article
Language:English
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Summary:Objective  Although autologous bone grafting is the most widely used treatment for bone defects, the most effective preparation remains unclear. This animal study aimed to compare different autologous bone grafting preparation for the treatment of rat́s calvaria critical bone defect. Methods  122 rats were randomly allocated into three groups: Simulado, Macerated and Chopped. The specimens underwent craniotomies at the top center of their calvarias with a 7mm diameter circumferential cutter drill. The critical bone defect produced was treated or not according to the group the specimen wasallocated. The rats were euthanized at 3, 6 or 12 weeks post-op and its calvarias were analyzed by histomorphometry, bone densitometry, nanocomputed tomography (nCT), and biomechanical tests. Results  The histomorphometry analysis showed the highest percentage of fulfillment of the critical bone defect in the chopped and macerated group when compared to simulado. The densitometry assessment evidenced higher bone mass at all endpoints analysis (p 
ISSN:0102-3616
1982-4378
DOI:10.1055/s-0044-1788786