Fluazifop, a grass-selective herbicide which inhibits acetyl-CoA carboxylase in sensitive plant species

Fluazifop is a grass-selective herbicide that appears to act by inhibiting fatty acid synthesis de novo in sensitive species. Results from four different types of experiment show that this inhibition is due to an action of fluazifop on acetyl-CoA carboxylase and not on fatty acid synthetase. The ace...

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Bibliographic Details
Published in:Biochemical journal 1988-08, Vol.254 (1), p.307-310
Main Authors: Walker, K.A, Ridley, S.M, Lewis, T, Harwood, J.L
Format: Article
Language:English
Subjects:
Acetates - metabolism
acetyl-CoA carboxylase
Acetyl-CoA Carboxylase - antagonists & inhibitors
chloroplasts
Chloroplasts - drug effects
Chloroplasts - enzymology
Dihydropyridines - pharmacology
Dose-Response Relationship, Drug
fatty acids
Fatty Acids - biosynthesis
fluazifop
herbicides
Herbicides - pharmacology
Hordeum vulgare
Ligases - antagonists & inhibitors
Malonyl Coenzyme A - metabolism
Pisum sativum
Plants - drug effects
Plants - enzymology
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Summary:Fluazifop is a grass-selective herbicide that appears to act by inhibiting fatty acid synthesis de novo in sensitive species. Results from four different types of experiment show that this inhibition is due to an action of fluazifop on acetyl-CoA carboxylase and not on fatty acid synthetase. The acetyl-CoA carboxylase from sensitive barley (Hordeum vulgare), but not from resistant pea (Pisum sativum), is inhibited by the R stereoisomer, a finding that agrees with the herbicidal specificity of fluazifop.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj2540307