Mucosal Healing Among Black and White Patients With Inflammatory Bowel Disease

INTRODUCTION: Crohn's disease and ulcerative colitis are characterized by chronic inflammation of the gastrointestinal tract. Mucosal healing (MH) is a therapeutic goal in patients with inflammatory bowel disease (IBD). Current data suggest that Black patients may experience worse clinical outc...

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Bibliographic Details
Published in:Clinical and translational gastroenterology 2024-08, Vol.15 (8), p.e00737
Main Authors: Dixit, Devika, Ruiz, Nicole C., Shen, Steve, Daneshmand, Arvin, Rodriguez, Vanessa I., Qian, Steve, Neal, Dan, Rampertab, S. Devi, Zimmermann, Ellen M., Kamel, Amir Y.
Format: Article
Language:English
Subjects:
Biological products
Clinical outcomes
Combination therapy
Crohns disease
Demographics
Electronic health records
Endoscopy
Health care access
Health disparities
Histology
Hospitalization
Immunomodulators
Inequality
Inflammation
Inflammatory Bowel Disease
Magnetic resonance imaging
Medical records
Patients
Race
Racial differences
Steroids
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Summary:INTRODUCTION: Crohn's disease and ulcerative colitis are characterized by chronic inflammation of the gastrointestinal tract. Mucosal healing (MH) is a therapeutic goal in patients with inflammatory bowel disease (IBD). Current data suggest that Black patients may experience worse clinical outcomes than White patients with IBD. This study assessed MH between Black and White patients with IBD. METHODS: Retrospective analysis was performed on Black and White adults with IBD who were hospitalized for an active flare. The presence of MH was assessed at 6–18 months after hospitalization. IBD treatments received before and during hospitalization, within 6 months, and 6–18 months after discharge were recorded. C-reactive protein (CRP) levels were collected at hospitalization and 6–18 months after discharge; the difference was reported as delta CRP. RESULTS: One hundred nine patients were followed up after hospitalization. Of those 88 (80.7%) were White patients, and 21 (19.3%) were Black patients. White and Black patients received similar proportions of IBD treatment before ( P = 0.2) and during ( P = 0.6) hospitalization, within 6 months ( P = 0.1), and 6–18 months ( P = 0.1) after discharge. Black patients achieved numerically higher rates of MH (15/21 = 71.4% vs 53/88 = 60.2%, P = 0.3) and delta CRP ( P = 0.2) than White patients, however, not statistically significant. DISCUSSION: In patients admitted to the hospital with an IBD flare with similar treatment and care, there was a trend toward higher rates of MH in Black patients compared with White patients. These data suggest that MH is likely not the only factor that is associated with Black patients experiencing worse clinical outcomes when compared with White patients.
ISSN:2155-384X
2155-384X
DOI:10.14309/ctg.0000000000000737