Segregation of two glutaminase isoforms in islets of Langerhans

Despite the importance of glutamatergic signalling in the co-ordination of hormone secretion, the identity of the enzyme for the production of glutamate in beta-cells is still unresolved. We have found that the endocrine pancreas co-expresses two isoforms of GA (glutaminase), denoted as kidney-type...

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Bibliographic Details
Published in:Biochemical journal 2004-07, Vol.381 (Pt 2), p.483-487
Main Authors: Baglietto-Vargas, David, López-Téllez, Juan F, Moreno-González, Inés, Gutiérrez, Antonia, Aledo, J Carlos
Format: Article
Language:English
Subjects:
Animals
Glutaminase - metabolism
Isoenzymes - metabolism
Kidney - enzymology
Langerhans Cells - enzymology
Liver - enzymology
Male
Rabbits
Rats
Rats, Sprague-Dawley
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Summary:Despite the importance of glutamatergic signalling in the co-ordination of hormone secretion, the identity of the enzyme for the production of glutamate in beta-cells is still unresolved. We have found that the endocrine pancreas co-expresses two isoforms of GA (glutaminase), denoted as kidney-type (KGA) and liver-type (LGA), with a complementary cellular pattern of expression. Whereas KGA was mainly present in alpha-cells, LGA was very abundant in beta-cells. This spatial segregation may have important functional implications, facilitating a differential regulation of glutamate production in insulin- and glucagon-secreting cells.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj20040523