Navigating glioblastoma complexity: the interplay of neurotransmitters and chromatin

Glioblastoma is the most aggressive brain cancer with an unfavorable prognosis for patient survival. Glioma stem cells, a subpopulation of cancer cells, drive tumor initiation, self-renewal, and resistance to therapy and, together with the microenvironment, play a crucial role in glioblastoma mainte...

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Bibliographic Details
Published in:Molecular biology reports 2024-12, Vol.51 (1), p.912
Main Authors: Romero-Reyes, Jessica, Vázquez-Martínez, Edgar Ricardo, Silva, Carlos-Camilo, Molina-Hernández, Anayansi, Díaz, Néstor Fabián, Camacho-Arroyo, Ignacio
Format: Article
Language:English
Subjects:
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Brain cancer
Brain tumors
Cancer
Cell self-renewal
Chromatin
Developmental plasticity
Dopamine
Epigenetics
Glioblastoma
Glioma
Glioma cells
Histology
Life Sciences
Medical prognosis
Microenvironments
Mini Review
Morphology
Neural plasticity
Neurotransmitters
Norepinephrine
Serotonin
Stem cells
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Summary:Glioblastoma is the most aggressive brain cancer with an unfavorable prognosis for patient survival. Glioma stem cells, a subpopulation of cancer cells, drive tumor initiation, self-renewal, and resistance to therapy and, together with the microenvironment, play a crucial role in glioblastoma maintenance and progression. Neurotransmitters such as noradrenaline, dopamine, and serotonin have contrasting effects on glioblastoma development, stimulating or inhibiting its progression depending on the cellular context and through their action on glioma stem cells, perhaps changing the epigenetic landscape. Recent studies have revealed that serotonin and dopamine induce chromatin modifications related to transcriptional plasticity in the mammalian brain and possibly in glioblastoma; however, this topic still needs to be explored because of its potential implications for glioblastoma treatment. Also, it is essential to consider that neurotransmitters’ effects depend on the tumor’s microenvironment since it can significantly influence the response and behavior of cancer cells. This review examines the possible role of neurotransmitters as regulators of glioblastoma development, focusing on their impact on the chromatin of glioma stem cells.
ISSN:0301-4851
1573-4978
1573-4978
DOI:10.1007/s11033-024-09853-3