The impact of magnesium biotinate and arginine silicate complexes on metabolic dysfunctions, antioxidant activity, inflammation, and neuromodulation in high-fat diet-fed rats

Biotin and arginine play crucial roles in lipid metabolism and may offer promising interventions against obesity. This study examined the combined effect of magnesium biotinate (MgB) and inositol-stabilized arginine silicate complex (ASI) on obesity-related oxidative imbalance, inflammation, lipid m...

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Bibliographic Details
Published in:Clinical and experimental medicine 2024-08, Vol.24 (1), p.176, Article 176
Main Authors: Sahin, Kazim, Sahin, Emre, Orhan, Cemal, Er, Besir, Akoglan, Bayram, Ozercan, Ibrahim Hanifi, Sahin, Nurhan, Komorowski, James R.
Format: Article
Language:English
Subjects:
Antioxidants
Arginine
Biotin
Body weight
Brain-derived neurotrophic factor
Cholesterol
Correspondence
Energy metabolism
Fat metabolism
Hematology
High fat diet
Hydroxymethylglutaryl-CoA reductase
Inflammation
Inositol
Insulin receptor substrate 1
Internal Medicine
Lipid metabolism
Lipids
Liver
Magnesium
Medicine
Medicine & Public Health
Metabolic pathways
Metabolism
Neuromodulation
Obesity
Oncology
Oxidative metabolism
Peroxisome proliferator-activated receptors
Sterol regulatory element-binding protein
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Summary:Biotin and arginine play crucial roles in lipid metabolism and may offer promising interventions against obesity. This study examined the combined effect of magnesium biotinate (MgB) and inositol-stabilized arginine silicate complex (ASI) on obesity-related oxidative imbalance, inflammation, lipid metabolism and neuromodulation in rats on a high-fat diet (HFD). Forty rats were divided into five groups: (a) control: rats were fed a standard diet containing 12% of energy from fat; (b) HFD: rats were fed the HFD with 42% of energy from fat; (c) HFD + MgB: rats were fed the HFD and given 0.31 mg/kg body weight (BW) MgB, (d) HFD + ASI: rats were fed the HFD and were given 12.91 mg/kg BW ASI), and (e) HFD + MgB + ASI: rats were fed the HFD and given 0.31 mg/kg BW MgB and 12.91 mg/kg BW ASI). The combined administration of MgB and ASI reduced the levels of serum cholesterol, free fatty acid (FFA), and malondialdehyde (MDA), as well as liver inflammatory cytokines, sterol regulatory element-binding protein 1-c (SREBP-1c), and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) proteins ( P  
ISSN:1591-9528
1591-8890
1591-9528
DOI:10.1007/s10238-024-01434-9