Relation Between Exposure to Tobacco Smoke Assessed by Serum Cotinine Concentration and Questionnaire Method, and Serum Renalase Concentration—the Importance of the Coexistence of Arterial Hypertension and Other Cardiovascular Diseases

Exposure to tobacco smoke (ETS) is one of the main risk factors for cardiovascular disease (CVD). Renalase is a protein that may play a role in the pathogenesis of CVD. The aim of the study was to assess the relationship between ETS and serum renalase concentration. A group of 109 patients was recru...

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Published in:Cardiovascular toxicology 2024-08, Vol.24 (8), p.737-746
Main Authors: Żórawik, Aleksandra, Hajdusianek, Wojciech, Kusnerż, Agnieszka, Markiewicz-Górka, Iwona, Jaremków, Aleksandra, Martynowicz, Helena, Pawlas, Krystyna, Mazur, Grzegorz, Poręba, Rafał, Gać, Paweł
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Blood levels
Blood pressure
Cardiology
Cardiovascular disease
Cardiovascular diseases
Coexistence
Coronary artery disease
Cotinine
Heart diseases
Pharmacology/Toxicology
Questionnaires
Risk factors
Smoke
Tobacco
Tobacco smoke
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Summary:Exposure to tobacco smoke (ETS) is one of the main risk factors for cardiovascular disease (CVD). Renalase is a protein that may play a role in the pathogenesis of CVD. The aim of the study was to assess the relationship between ETS and serum renalase concentration. A group of 109 patients was recruited for this study (49.7 ± 14.7 years). In accordance with the questionnaire, patients were divided into the following subgroups: subgroup A– declaring themselves active smokers ( n  = 36), subgroup B– declaring themselves non-smokers and exposed to environmental tobacco smoke ( n  = 35), subgroup C– declaring themselves non-smokers and not exposed to environmental tobacco smoke ( n  = 38). The same patients were divided based on cotinine concentration into the following subgroups: subgroup D– active smokers ( n  = 42), subgroup E– non-smokers exposed to environmental tobacco smoke ( n  = 66), and subgroup F– non-smokers not exposed to environmental tobacco smoke ( n  = 1). Serum cotinine concentration and serum renalase concentration were measured using ELISA tests. Serum renalase concentration was statistically significantly higher in subgroup C than in subgroups A and B and in subgroup E and F than in D. There was a negative correlation between serum cotinine concentration and serum renalase concentration (r = −0.41, p 
ISSN:1530-7905
1559-0259
1559-0259
DOI:10.1007/s12012-024-09868-z