Amniotic miracle: Investigating the unique development and applications of amniotic membrane in wound healing

Background The perfect repair of damaged skin has always been a constant goal for scientists; however, the repair and reconstruction of skin is still a major problem and challenge in injury and burns medicine. Human amniotic membrane (hAM), with its good mechanical properties and anti‐inflammatory,...

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Bibliographic Details
Published in:Skin research and technology 2024-07, Vol.30 (7), p.e13860-n/a
Main Authors: Guo, Xinya, Zhang, Wei, Lu, Jianyu, Zhu, Yushu, Sun, Hanlin, Xu, Dayuan, Xian, Shuyuan, Yao, Yuntao, Qian, Weijin, Lu, Bingnan, Shi, Jiaying, Ding, Xiaoyi, Li, Yixu, Tong, Xirui, Xiao, Shichu, Huang, Runzhi, Ji, Shizhao
Format: Article
Language:English
Subjects:
Amniotic membrane
Bibliometrics
Dynamic structural analysis
Foci
Growth factors
Historical structures
History of engineering
Mechanical properties
Medical dressings
Membranes
Mesenchymal stem cells
Nanocomposites
Original
R&D
Regenerative medicine
Research & development
Research facilities
Research hot spots
Research programs
Scaffolds
Skin
Stem cells
Tissue engineering
Trends
Wound healing
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Summary:Background The perfect repair of damaged skin has always been a constant goal for scientists; however, the repair and reconstruction of skin is still a major problem and challenge in injury and burns medicine. Human amniotic membrane (hAM), with its good mechanical properties and anti‐inflammatory, antioxidant and antimicrobial benefits, containing growth factors that promote wound healing, has evolved over the last few decades from simple skin sheets to high‐tech dressings, such as being made into nanocomposites, hydrogels, powders, and electrostatically spun scaffolds. This paper aims to explore the historical development, applications, trends, and research hotspots of hAM in wound healing. Methods We examined 2660 publications indexed in the Web of Science Core Collection (WoSCC) from January 1, 1975 to July 12, 2023. Utilizing bibliometric methods, we employed VOSviewer, CiteSpace, and R‐bibliometrix to characterize general information, identify development trends, and highlight research hotspots. Subsequently, we identified a collection of high‐quality English articles focusing on the roles of human amniotic epithelial stem cells (hAESCs), human amniotic mesenchymal stem cells (hAMSCs), and amniotic membrane (AM) scaffolds in regenerative medicine and tissue engineering. Results Bibliometric analysis identified Udice–French Research Universities as the most productive affiliation and Tseng S.C.G. as the most prolific author. Keyword analysis, historical direct quotations network, and thematic analysis helped us review the historical and major themes in this field. Our examination included the knowledge structure, global status, trends, and research hotspots regarding the application of hAM in wound healing. Our findings indicate that contemporary research emphasizes the preparation and application of products derived from hAM. Notably, both hAM and the cells isolated from it – hADSCs and hAESCs are prominent and promising areas of research in regenerative medicine and tissue engineering. Conclusion This research delivers a comprehensive understanding of the knowledge frameworks, global dynamics, emerging patterns, and primary research foci in the realm of hAM applications for wound healing. The field is rapidly evolving, and our findings offer valuable insights for researchers. Future research outcomes are anticipated to be applied in clinical practice, enhancing methods for disease prevention, diagnosis, and treatment.
ISSN:0909-752X
1600-0846
1600-0846
DOI:10.1111/srt.13860