Association of routine hematological parameters with the development of monoclonal gammopathies: a case-control study of 134,740 patients

The diagnosis of multiple myeloma requires detection of paraproteinemia and confirmation of monoclonal bone marrow infiltration, along with signs of end-organ damage. Despite the increasing prevalence, serum paraproteinemia is not routinely measured. We examined the relationship between alterations...

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Bibliographic Details
Published in:Annals of hematology 2024-08, Vol.103 (8), p.3005-3013
Main Authors: Røllum-Larsen, Jakob, Engell, Anna Elise, Diaz-delCastillo, Marta, Heegaard, Anne-Marie, Jørgensen, Henrik Løvendahl
Format: Article
Language:English
Subjects:
Hematology
Hemoglobin
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Summary:The diagnosis of multiple myeloma requires detection of paraproteinemia and confirmation of monoclonal bone marrow infiltration, along with signs of end-organ damage. Despite the increasing prevalence, serum paraproteinemia is not routinely measured. We examined the relationship between alterations in routine hematological parameters and the development of paraproteinemia in a case-control study. Data was retrieved from a laboratory database in the capital region of Denmark between 01/01/2012 and 31/12/2022. Patients were included if they had a test for paraproteinemia (n = 134,740) and at least one prior hematological parameter (white blood cells, hemoglobin and platelet count) with a minimum follow-up of 1 year.Between 96,999 and 103,590 patients were included in each of the three hematological groups. We found white blood cell count and the presence of paraproteinemia followed an inverse J-shaped curve, with the highest presence below 3 × 109/L and above > 9 × 109/L. The adjusted OR below and above the nadir of 4 × 109/L was 1.61 (95% CI 1.25; 2.08, p 
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-024-05822-9