Comparing contribution of bony and cartilaginous endplate changes to intervertebral disc degeneration

Objective: To compare the degenerative features of cartilaginous endplate with bony endplate in association with intervertebral degeneration in local population at radiographic, macroscopic and microscopic level in human motion segments. Methods: This cross-sectional descriptive study examined 59 lu...

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Bibliographic Details
Published in:Pakistan journal of medical sciences 2024-08, Vol.40 (7), p.1516-1522
Main Authors: Salman, Amber, Khawaja, Asma Sajjad, Baig, Kashif, Zehra, Uruj
Format: Article
Language:English
Subjects:
Back pain
Backache
Cadavers
Calcification
Degenerative disc disease
Fractures
Health sciences
Medical research
Medicine, Experimental
Original
Physiological aspects
Vertebrae
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Summary:Objective: To compare the degenerative features of cartilaginous endplate with bony endplate in association with intervertebral degeneration in local population at radiographic, macroscopic and microscopic level in human motion segments. Methods: This cross-sectional descriptive study examined 59 lumbar spine motion segments from adult male cadavers at the Department of Anatomy, University of Health Sciences, Lahore, between May and September, 2022. Radiographic assessment observed bony endplate (BEP) for the presence of sclerosis & osteophytes and degeneration scores from 1-8 were assigned. Macroscopic assessment was done to evaluate BEP, cartilaginous endplate (CEP) and IVD, and scores ranged from 1to 28 for BEP, 1-4 for CEP and 1-64 for IVD were assigned. Microscopic assessment revealed degeneration scores of CEP ranged from 1-42 and 1-30 for IVD. Segments with BEP defects were also identified on radiographs & macroscopy. Results: Significant correlations were observed between the total degeneration scores of BEP with IVD and CEP scores (r=0.88 and r=0.909, respectively, p
ISSN:1682-024X
1681-715X
DOI:10.12669/pjms.40.7.8762