α7 nicotinic acetylcholine receptor agonist attenuates allergen-induced immediate nasal response in murine model of allergic rhinitis

The expression of nicotinic acetylcholine receptor (nAChR) subunits on various immune cells suggests their involvement in allergic rhinitis. However, how exactly they contribute to this pathogenesis is not yet confirmed. Our present study examined the therapeutic potential of GTS-21, an α7 nAChR ago...

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Published in:Journal of Veterinary Medical Science 2024, Vol.86(7), pp.824-827
Main Authors: YAMASHITA, Shuhei, MIURA, Kento, MATSUURA, Anna, YAMASAKI, Norimasa, UDA, Naoto, OGATA, Sawako, HOSOMI, Naohisa, NAKAJIMA, Shotaro, KITAMURA, Noriko, GOTOH, Minoru, MORI, Akio, KAMINUMA, Osamu
Format: Article
Language:English
Subjects:
Acetylcholine receptors (nicotinic)
Agonists
Allergens
Allergic rhinitis
Allergies
Anaphylaxis
Animal models
Leukocytes (eosinophilic)
Lymphocytes T
Mast cells
murine model
Ovalbumin
Passive cutaneous anaphylaxis
Pharmacology
α7 nicotinic acetylcholine receptor
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Summary:The expression of nicotinic acetylcholine receptor (nAChR) subunits on various immune cells suggests their involvement in allergic rhinitis. However, how exactly they contribute to this pathogenesis is not yet confirmed. Our present study examined the therapeutic potential of GTS-21, an α7 nAChR agonist, for treating allergic rhinitis by employing its mouse models. GTS-21 treatment reduced allergen-induced immediate nasal response in ovalbumin (OVA)-sensitized model. However, nasal hyperresponsiveness or eosinophil infiltration elicited in either the OVA-sensitized or T helper 2 cell-transplanted model was not affected by GTS-21. GTS-21 did not alter allergen-induced passive cutaneous anaphylaxis response in anti-dinitrophenyl IgE-sensitized mice. This evidence implies GTS-21’s potential to alleviate allergic rhinitis without perturbing T cells or mast cells.
ISSN:0916-7250
1347-7439
1347-7439
DOI:10.1292/jvms.24-0033