Social determinants of health but not global genetic ancestry predict dementia prevalence in Latin America

INTRODUCTION Leveraging the nonmonolithic structure of Latin America, which represents a large variability in social determinants of health (SDoH) and high levels of genetic admixture, we aim to evaluate the relative contributions of SDoH and genetic ancestry in predicting dementia prevalence in Lat...

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Published in:Alzheimer's & dementia 2024-07, Vol.20 (7), p.4828-4840
Main Authors: Llibre‐Guerra, Jorge J., Jiang, Miao, Acosta, Isaac, Sosa, Ana Luisa, Acosta, Daisy, Jimenez‐Velasquez, Ivonne Z., Guerra, Mariella, Salas, Aquiles, Rodriguez Salgado, Ana M., Llibre‐Guerra, Juan C., Sánchez, Nedelys Díaz, Prina, Matthew, Renton, Alan, Albanese, Emiliano, Yokoyama, Jennifer S., Llibre Rodriguez, Juan J.
Format: Article
Language:English
Subjects:
ancestry
dementia
Latinos
prevalence
risk factors
social determinants of health
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Summary:INTRODUCTION Leveraging the nonmonolithic structure of Latin America, which represents a large variability in social determinants of health (SDoH) and high levels of genetic admixture, we aim to evaluate the relative contributions of SDoH and genetic ancestry in predicting dementia prevalence in Latin American populations. METHODS Community‐dwelling participants aged 65 and older (N = 3808) from Cuba, Dominican Republic, Mexico, and Peru completed the 10/66 protocol assessments. Dementia was diagnosed using the cross‐culturally validated 10/66 algorithm. Multivariate linear regression models adjusted for SDoH were used in the main analysis. This study used cross‐sectional data from the 1066 population‐based study. RESULTS Individuals with higher proportions of Native American (>70%) and African American (>70%) ancestry were more likely to exhibit factors contributing to worse SDoH, such as lower educational levels (p 
ISSN:1552-5260
1552-5279
1552-5279
DOI:10.1002/alz.14041