Association of spermidine plasma levels with brain aging in a population‐based study

Introduction Supplementation with spermidine may support healthy aging, but elevated spermidine tissue levels were shown to be an indicator of Alzheimer's disease (AD). Methods Data from 659 participants (age range: 21–81 years) of the population‐based Study of Health in Pomerania TREND were in...

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Published in:Alzheimer's & dementia 2023-05, Vol.19 (5), p.1832-1840
Main Authors: Wortha, Silke M., Frenzel, Stefan, Bahls, Martin, Habes, Mohamad, Wittfeld, Katharina, Van der Auwera, Sandra, Bülow, Robin, Zylla, Stephanie, Friedrich, Nele, Nauck, Matthias, Völzke, Henry, Grabe, Hans J., Schwarz, Claudia, Flöel, Agnes
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging - pathology
Alzheimer Disease - pathology
Alzheimer's disease
Brain - diagnostic imaging
Brain - pathology
cortical thickness
epidemiology
hippocampal volume
Humans
Magnetic Resonance Imaging
Middle Aged
Spermidine
White Matter - pathology
white matter hyperintensities
Young Adult
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Summary:Introduction Supplementation with spermidine may support healthy aging, but elevated spermidine tissue levels were shown to be an indicator of Alzheimer's disease (AD). Methods Data from 659 participants (age range: 21–81 years) of the population‐based Study of Health in Pomerania TREND were included. We investigated the association between spermidine plasma levels and markers of brain aging (hippocampal volume, AD score, global cortical thickness [CT], and white matter hyperintensities [WMH]). Results Higher spermidine levels were significantly associated with lower hippocampal volume (ß = −0.076; 95% confidence interval [CI]: −0.13 to −0.02; q = 0.026), higher AD score (ß = 0.118; 95% CI: 0.05 to 0.19; q = 0.006), lower global CT (ß = −0.104; 95% CI: −0.17 to −0.04; q = 0.014), but not WMH volume. Sensitivity analysis revealed no substantial changes after excluding participants with cancer, depression, or hemolysis. Discussion Elevated spermidine plasma levels are associated with advanced brain aging and might serve as potential early biomarker for AD and vascular brain pathology.
ISSN:1552-5260
1552-5279
1552-5279
DOI:10.1002/alz.12815