Changes in Intervertebral Disc Properties after Intradiscal Injection of Condoliase for Painful Lumbar Disc Herniation

The detailed changes in disc properties after intradiscal injection of condoliase remain controversial. At 3 and 9 months after administration, radiographic changes in discs were investigated. A total of 41 patients (men, 25; median age, 46 years) who underwent regular follow-up magnetic resonance i...

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Bibliographic Details
Published in:Neurologia Medico-Chirurgica 2024/06/15, Vol.64(6), pp.222-229
Main Authors: OHTONARI, Tatsuya, SAKAI, Kyohei, FURUKAWA, Yosuke, TAKEDA, Yasushi
Format: Article
Language:English
Subjects:
chemonucleolysis
chondroitin sulfate ABC endolyase
condoliase
degeneration
Injection
Intervertebral discs
lumbar disc herniation
Magnetic resonance imaging
Nucleus pulposus
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Summary:The detailed changes in disc properties after intradiscal injection of condoliase remain controversial. At 3 and 9 months after administration, radiographic changes in discs were investigated. A total of 41 patients (men, 25; median age, 46 years) who underwent regular follow-up magnetic resonance imaging at 3 and 9 months after administration without additional invasive therapy were retrospectively investigated. The intensity changes of the nucleus pulposus based on the Pfirrmann disc grading system, midsagittal disc height, and maximum protrusion length of herniation were assessed. In addition, disc height changes were compared between 24 patients aged 11 mm had the greatest reduction in disc height than the over 50s group. In conclusion, the clinical outcomes in the over 50s group were comparable to those in the young group after injection of condoliase, whereas young patients with higher disc were more susceptible to disc height reduction.
ISSN:0470-8105
1349-8029
DOI:10.2176/jns-nmc.2023-0302