Greater myofibrillar protein synthesis following weight-bearing activity in obese old compared with non-obese old and young individuals

The mechanisms through which obesity impacts age-related muscle mass regulation are unclear. In the present study, rates of integrated myofibrillar protein synthesis (iMyoPS) were measured over 48-h prior-to and following a 45-min treadmill walk in 10 older-obese (O-OB, body fat[%]: 33 ± 3%), 10 old...

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Bibliographic Details
Published in:GeroScience 2023-06, Vol.46 (4), p.3759-3778
Main Authors: Morgan, Paul T., Smeuninx, Benoit, Marshall, Ryan N., Korzepa, Marie, Quinlan, Jonathan I., McPhee, Jamie S., Breen, Leigh
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Body fat
Cell Biology
Electromyography
Geriatrics/Gerontology
Life Sciences
Magnetic resonance imaging
Molecular Medicine
Muscle contraction
Obesity
Original
Original Article
Protein biosynthesis
Protein synthesis
Quadriceps muscle
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Summary:The mechanisms through which obesity impacts age-related muscle mass regulation are unclear. In the present study, rates of integrated myofibrillar protein synthesis (iMyoPS) were measured over 48-h prior-to and following a 45-min treadmill walk in 10 older-obese (O-OB, body fat[%]: 33 ± 3%), 10 older-non-obese (O-NO, 20 ± 3%), and 15 younger-non-obese (Y-NO, 13 ± 5%) individuals. Surface electromyography was used to determine thigh muscle “activation”. Quadriceps cross-sectional area (CSA), volume, and intramuscular thigh fat fraction (ITFF) were measured by magnetic resonance imaging. Quadriceps maximal voluntary contraction (MVC) was measured by dynamometry. Quadriceps CSA and volume were greater (muscle volume, Y-NO: 1182 ± 232 cm 3 ; O-NO: 869 ± 155 cm 3 ; O-OB: 881 ± 212 cm 3 , P  
ISSN:2509-2723
2509-2715
2509-2723
DOI:10.1007/s11357-023-00833-2