Hand joints without radiographic osteoarthritis maintain their joint space width over 4 years despite what’s happening elsewhere in the hand

Abstract Objectives We aimed to determine whether hand OA is characterized by systemic cartilage loss by assessing if radiographically normal joints had greater joint space width (JSW) loss over 4 years in hands with incident or prevalent OA elsewhere in the hand compared with hands without OA. Meth...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2024-07, Vol.63 (7), p.1850-1855
Main Authors: Driban, Jeffrey B, Vo, Nhung, Duryea, Jeff, Schaefer, Lena F, Haugen, Ida K, Eaton, Charles B, Roberts, Mary B, Lu, Bing, McAlindon, Timothy
Format: Article
Language:English
Subjects:
Cartilage
Cartilage diseases
Clinical Science
Osteoarthritis
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Summary:Abstract Objectives We aimed to determine whether hand OA is characterized by systemic cartilage loss by assessing if radiographically normal joints had greater joint space width (JSW) loss over 4 years in hands with incident or prevalent OA elsewhere in the hand compared with hands without OA. Methods We used semi-automated software to measure JSW in the distal and proximal IP joints of 3368 participants in the Osteoarthritis Initiative who had baseline and 48-month hand radiographs. A reader scored 16 hand joints (including the thumb base) for Kellgren–Lawrence (KL) grade. A joint had OA if scored as KL ≥2. We identified three groups based on longitudinal hand OA status: no hand OA (KL
ISSN:1462-0324
1462-0332
1462-0332
DOI:10.1093/rheumatology/kead480