Associations of a Prenatal Serum Per- and Polyfluoroalkyl Substance Mixture with the Cord Serum Metabolome in the HOME Study

Per- and polyfluoroalkyl substances (PFAS) are ubiquitous and persistent chemicals associated with multiple adverse health outcomes; however, the biological pathways affected by these chemicals are unknown. To address this knowledge gap, we used data from 264 mother–infant dyads in the Health Outcom...

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Bibliographic Details
Published in:Environmental science & technology 2023-12, Vol.57 (51), p.21627-21636
Main Authors: Hall, Amber M., Fleury, Elvira, Papandonatos, George D., Buckley, Jessie P., Cecil, Kim M., Chen, Aimin, Lanphear, Bruce P., Yolton, Kimberly, Walker, Douglas I., Pennell, Kurt D., Braun, Joseph M., Manz, Katherine E.
Format: Article
Language:English
Subjects:
Alkanesulfonic Acids
Amino acids
Biosynthesis
Birth weight
Carbohydrates
Child
Computation
Ecotoxicology and Public Health
Environmental Pollutants
Female
Fluorocarbons
Glycan
Humans
Infant
Infants
Lipids
Metabolic pathways
Metabolism
Metabolites
Metabolome
Mixtures
Perfluoro compounds
Perfluoroalkyl & polyfluoroalkyl substances
Perfluorochemicals
Perfluorooctane sulfonic acid
Perfluorooctanoic acid
Pregnancy
Prenatal experience
Quantiles
Retention time
Vaccines
Vitamins
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Summary:Per- and polyfluoroalkyl substances (PFAS) are ubiquitous and persistent chemicals associated with multiple adverse health outcomes; however, the biological pathways affected by these chemicals are unknown. To address this knowledge gap, we used data from 264 mother–infant dyads in the Health Outcomes and Measures of the Environment (HOME) Study and employed quantile-based g-computation to estimate covariate-adjusted associations between a prenatal (∼16 weeks’ gestation) serum PFAS mixture [perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexanesulfonic acid (PFHxS), and perfluorononanoic acid (PFNA)] and 14,402 features measured in cord serum. The PFAS mixture was associated with four features: PFOS, PFHxS, a putatively identified metabolite (3-monoiodo-l-thyronine 4-O-sulfate), and an unidentified feature (590.0020 m/z and 441.4 s retention time; false discovery rate
ISSN:0013-936X
1520-5851
1520-5851
DOI:10.1021/acs.est.3c07515