Thoracic aortic microcalcification activity in combined positron emission tomography and magnetic resonance imaging

Introduction Non-invasive detection of pathological changes in thoracic aortic disease remains an unmet clinical need particularly for patients with congenital heart disease. Positron emission tomography combined with magnetic resonance imaging (PET-MRI) could provide a valuable low-radiation method...

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Published in:European journal of nuclear medicine and molecular imaging 2024-07, Vol.51 (8), p.2260-2270
Main Authors: Nash, Jennifer, Debono, Samuel, Whittington, Beth, Kaczynski, Jakub, Clark, Tim, Macnaught, Gillian, Semple, Scott, van Beek, Edwin J R, Tavares, Adriana, Dey, Damini, Williams, Michelle C, Slomka, Piotr J, Newby, David E, Dweck, Marc R, Fletcher, Alexander J
Format: Article
Language:English
Subjects:
Aorta
Aortic valve
Atria
Attenuation
Cardiology
Computed tomography
Fluorides
Fluorine isotopes
Heart diseases
Heart valves
Image processing
Image reconstruction
Image segmentation
Imaging
Magnetic resonance imaging
Medical imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Oncology
Original
Original Article
Orthopedics
Positron emission
Positron emission tomography
Radioactive tracers
Radiology
Rheumatic heart disease
Risk groups
Sodium
Soft tissues
Surveillance
Thorax
Tomography
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Summary:Introduction Non-invasive detection of pathological changes in thoracic aortic disease remains an unmet clinical need particularly for patients with congenital heart disease. Positron emission tomography combined with magnetic resonance imaging (PET-MRI) could provide a valuable low-radiation method of aortic surveillance in high-risk groups. Quantification of aortic microcalcification activity using sodium [ 18 F]fluoride holds promise in the assessment of thoracic aortopathies. We sought to evaluate aortic sodium [ 18 F]fluoride uptake in PET-MRI using three methods of attenuation correction compared to positron emission tomography computed tomography (PET-CT) in patients with bicuspid aortic valve, Methods Thirty asymptomatic patients under surveillance for bicuspid aortic valve disease underwent sodium [ 18 F]fluoride PET-CT and PET-MRI of the ascending thoracic aorta during a single visit. PET-MRI data were reconstructed using three iterations of attenuation correction (Dixon, radial gradient recalled echo with two [RadialVIBE-2] or four [RadialVIBE-4] tissue segmentation). Images were qualitatively and quantitatively analysed for aortic sodium [ 18 F]fluoride uptake on PET-CT and PET-MRI. Results Aortic sodium [ 18 F]fluoride uptake on PET-MRI was visually comparable with PET-CT using each reconstruction and total aortic standardised uptake values on PET-CT strongly correlated with each PET-MRI attenuation correction method (Dixon R  = 0.70; RadialVIBE-2 R  = 0.63; RadialVIBE-4 R  = 0.64; p  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-024-06670-5