Evolution of virulence factors in Shiga-toxin-producing Escherichia coli

The major demonstrated or putative virulence factors of Shiga-toxin-producing Escherichia coli (STEC) are the Shiga toxins, products of the locus of enterocyte effacement, and products encoded by the EHEC-hemolysin plasmid. Molecular analysis shows that STEC acquired the majority of these virulence...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 1999-11, Vol.56 (9-10), p.735-741
Main Author: Boerlin, P
Format: Article
Language:English
Subjects:
E coli
Escherichia coli
Escherichia coli - genetics
Escherichia coli - metabolism
Escherichia coli - pathogenicity
Escherichia coli - virology
Evolution
Evolution, Molecular
Gene Transfer, Horizontal
Genes
Genes, Bacterial - genetics
Hemolysin Proteins - genetics
Microbiology
Phylogeny
Plasmids - genetics
Recombination, Genetic - genetics
Shiga Toxin - genetics
Shiga Toxin - metabolism
Toxins
Virology
Virulence - genetics
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Summary:The major demonstrated or putative virulence factors of Shiga-toxin-producing Escherichia coli (STEC) are the Shiga toxins, products of the locus of enterocyte effacement, and products encoded by the EHEC-hemolysin plasmid. Molecular analysis shows that STEC acquired the majority of these virulence factors by horizontal transfer of genetic material. In the case of Shiga toxins, the phages encoding them are probably responsible for this transfer. For the locus of enterocyte effacement, however, it is not clear how often this transfer took place and which parts of the locus were involved in this transfer. The large EHEC-hemolysin plasmid is clearly a mosaic structure, which arose from multiple recombination events with foreign DNA. Two lineages of this plasmid can be distinguished, one of which is associated with chromosomally encoded virulence factors. Despite the wealth of information available, further comparative studies are needed to decipher definitively the evolution of virulence in STEC.
ISSN:1420-682X
1420-9071
DOI:10.1007/s000180050020