Endothelin-like peptides

Mammalian endothelins (ETs) and snake venom sarafotoxins (SRTXs) comprise structurally and functionally related potent vasoconstrictor isopeptides that act on the vascular system via identical receptors. This similarity is remarkable, since SRTXs are highly toxic components isolated from the venoms...

Full description

Saved in:
Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2005-12, Vol.62 (23), p.2828-2839
Main Author: Ducancel, F
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Endothelins - chemistry
Endothelins - pharmacology
Endothelins - physiology
Mammals
Models, Molecular
Molecular Sequence Data
Peptides
Peptides - chemistry
Peptides - pharmacology
Peptides - physiology
Review
Sequence Homology, Amino Acid
Species Specificity
Structure-Activity Relationship
Viper Venoms - chemistry
Viper Venoms - metabolism
Viper Venoms - pharmacology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mammalian endothelins (ETs) and snake venom sarafotoxins (SRTXs) comprise structurally and functionally related potent vasoconstrictor isopeptides that act on the vascular system via identical receptors. This similarity is remarkable, since SRTXs are highly toxic components isolated from the venoms of snakes of the genus Atractaspis of the Atractaspididae family, while ETs are endogenous hormones of the mammalian vascular system. Since the first functional and structural description of SRTXs in 1988, the full extent of their natural diversity has become increasingly apparent, and this has led to the characterization of new families of endothelin-like peptides. Based on a combination of conventional biochemical approaches and the latest molecular biology and mass spectrometry techniques, this review describes the more recent panel of SRTX isopeptides isolated from various snake species within the Atractaspididae family, but also the similarities and differences that exist between sarafotoxins and endothelins in terms of their metabolism, genetic origin, structure and functional sites.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-005-5286-x