Adtrp regulates thermogenic activity of adipose tissue via mediating the secretion of S100b

Brown and beige adipose tissues dissipate chemical energy in the form of heat to maintain your body temperature in cold conditions. The impaired function of these tissues results in various metabolic diseases in humans and mice. By bioinformatical analyses, we identified a functional thermogenic reg...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2022-08, Vol.79 (8), p.407-407, Article 407
Main Authors: Li, Peng, Song, Runjie, Du, Yaqi, Liu, Huijiao, Li, Xiangdong
Format: Article
Language:English
Subjects:
Abnormalities
Adipocytes
Adipocytes, Brown - metabolism
Adipose Tissue
Adipose tissue (brown)
Adipose Tissue, Brown - metabolism
Adipose Tissue, White - metabolism
Adrenergic receptors
Animal tissues
Animals
Biochemistry
Biomedical and Life Sciences
Biomedicine
Body fat
Body temperature
Calcium-binding protein
Cell Biology
Chemical energy
Cold Temperature
Innervation
Intolerance
Life Sciences
Lipids
Lipoproteins
Membrane Proteins - metabolism
Metabolic disorders
Metabolism
Mice
Original
Original Article
Protein B
Proteins
Receptors (physiology)
S100 Calcium Binding Protein beta Subunit - genetics
S100b protein
Secretion
Thermogenesis
Tissue factor
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Summary:Brown and beige adipose tissues dissipate chemical energy in the form of heat to maintain your body temperature in cold conditions. The impaired function of these tissues results in various metabolic diseases in humans and mice. By bioinformatical analyses, we identified a functional thermogenic regulator of adipose tissue, Androgen-dependent tissue factor pathway inhibitor [TFPI]-regulating protein ( Adtrp ), which was significantly overexpressed in and functionally activated the mature brown/beige adipocytes. Hereby, we knocked out Adtrp in mice which led to multiple abnormalities in thermogenesis, metabolism, and maturation of brown/beige adipocytes causing excess lipid accumulation in brown adipose tissue (BAT) and cold intolerance. The capability of thermogenesis in brown/beige adipose tissues could be recovered in Adtrp KO mice upon direct β3-adrenergic receptor (β3-AR) stimulation by CL316,243 treatment. Our mechanistic studies revealed that Adtrp by binding to S100 calcium-binding protein b (S100b) indirectly mediated the secretion of S100b, which in turn promoted the β3-AR mediated thermogenesis via sympathetic innervation. These results may provide a novel insight into Adtrp in metabolism via regulating the differentiation and thermogenesis of adipose tissues in mice.
ISSN:1420-682X
1420-9071
DOI:10.1007/s00018-022-04441-9