Whole genome‐wide sequence analysis of long‐lived families (Long‐Life Family Study) identifies MTUS2 gene associated with late‐onset Alzheimer's disease

INTRODUCTION Late‐onset Alzheimer's disease (LOAD) has a strong genetic component. Participants in Long‐Life Family Study (LLFS) exhibit delayed onset of dementia, offering a unique opportunity to investigate LOAD genetics. METHODS We conducted a whole genome sequence analysis of 3475 LLFS memb...

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Published in:	Alzheimer's & dementia 2024-04, Vol.20 (4), p.2670-2679
Main Authors:	Vardarajan, Badri, Andersen, Stacy L., Thyagarajan, Bharat, Yashin, Anatoli, Krinsky‐McHale, Sharon, Handen, Benjamin L., Schupf, Nicole, Lee, Joseph H., Barral, Sandra, Bell, Karen, Bulova, Peter, Cohen, Ann D., Constantino, John N., Head, Elizabeth, Honig, Lawrence, Ikonomovic, Milos D., Keator, David, Lao, Patrick, Lott, Ira T., Mapstone, Mark, Parisi, Melissa, Pulsifer, Margaret, Varadarajan, Badri, Zaman, Shahid, Adams, Perrie M., Allen, Mariet, Atwood, Craig S., Ayres, Gayle, Beecham, Gary W., Biber, Sarah A., Boeve, Bradley F., Bush, William S., Byrd, Goldie, Chan, Kwun C., Chen, Yen‐Chi, Chesselet, Marie‐Francoise, Chin, Nathaniel A., Cranney, Marissa, Cruchaga, Carlos, DeToledo, John C., Ertekin‐Taner, Nilufer, Faber, Kelley M., Fallin, Daniele, Farrer, Lindsay A., Galasko, Douglas R., Gefen, Tamar, Goate, Alison M., Grabowski, Thomas, Haines, Jonathan L., Hakonarson, Hakon, Hall, Kathleen, Hall, James R., Harari, Oscar, Honig, Lawrence S., Hyman, Bradley T., Hynan, Linda, Johnson, Kimberly, Jun, Gyungah, Kamboh, M. Ilyas, Khaleeq, Aisha, Kunkle, Brian W., LaFerla, Frank M., Lah, James J., Lieberman, Andrew P., Lipton, Richard B., Lopez, Oscar L., Marquez, David, Marson, Daniel C., Masurkar, Arjun V., Mukherjee, Shubhabrata, Nudelman, Kelley, Parisi, Joseph E., Pavlik, Valory, Perez, Victoria, Petersen, Ronald C., Polk, Marsha, Qu, Liming, Quiceno, Mary, Raj, Ashok, Rajabli, Farid, Roberson, Erik D., Royall, Donald R., Sano, Mary, Song, Yeunjoo, George‐Hyslop, Peter St, Stern, Robert A., Stevens, Alan, Sultzer, David, Valladares, Otto, Van Deerlin, Vivianna M., Vance, Jeffery M., Vassar, Robert, Welsh‐Bohmer, Kathleen A., Wilms, Henrick, Wisniewski, Thomas, Woon, Martin, Younkin, Steven G., Zhu, Congcong
Format:	Article
Language:	eng
Subjects:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Amyloid beta-Peptides - metabolism Genetic Predisposition to Disease genetic risk Genome-Wide Association Study - methods Humans late‐onset Alzheimer's disease microtubule protein Microtubule-Associated Proteins MTUS2 gene Polymorphism, Single Nucleotide - genetics Sequence Analysis whole genome sequence
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