CAnceR IN PreGnancy (CARING) - a retrospective study of cancer diagnosed during pregnancy in the United Kingdom

The incidence of cancer diagnosed during pregnancy is increasing. Data relating to investigation and management, as well as maternal and foetal outcomes is lacking in a United Kingdom (UK) population. In this retrospective study we report data from 119 patients diagnosed with cancer during pregnancy...

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Published in:British journal of cancer 2024-05, Vol.130 (8), p.1261-1268
Main Authors: Baxter, M A, Denholm, M, Kingdon, S J, Kathirgamakarthigeyan, S, Parikh, S, Shakir, R, Johnson, R, Martin, H, Walton, M, Yao, W, Swan, A, Samuelson, C, Ren, X, Cooper, A, Gray, H-L, Clifton, S, Ball, J, Gullick, G, Anderson, M, Dodd, L, Hayhurst, H, Salama, M, Shotton, R, Britton, F, Christodoulou, T, Abdul-Hamid, A, Eichholz, A, Evans, R M, Wallroth, P, Gibson, F, Poole, K, Rowe, M, Harris, J
Format: Article
Language:English
Subjects:
Cancer
Cesarean Section
Chemotherapy
Data collection
Diagnosis
Female
Humans
Live Birth
Neoplasms - diagnosis
Neoplasms - epidemiology
Neoplasms - therapy
Patients
Pregnancy
Retrospective Studies
United Kingdom - epidemiology
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Summary:The incidence of cancer diagnosed during pregnancy is increasing. Data relating to investigation and management, as well as maternal and foetal outcomes is lacking in a United Kingdom (UK) population. In this retrospective study we report data from 119 patients diagnosed with cancer during pregnancy from 14 cancer centres in the UK across a five-year period (2016-2020). Median age at diagnosis was 33 years, with breast, skin and haematological the most common primary sites. The majority of cases were new diagnoses (109 patients, 91.6%). Most patients were treated with radical intent (96 patients, 80.7%), however, gastrointestinal cancers were associated with a high rate of palliative intent treatment (63.6%). Intervention was commenced during pregnancy in 68 (57.1%) patients; 44 (37%) had surgery and 31 (26.1%) received chemotherapy. Live births occurred in 98 (81.7%) of the cases, with 54 (55.1%) of these delivered by caesarean section. Maternal mortality during the study period was 20.2%. This is the first pan-tumour report of diagnosis, management and outcomes of cancer diagnosed during pregnancy in the UK. Our findings demonstrate proof of concept that data collection is feasible and highlight the need for further research in this cohort of patients.
ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/s41416-024-02605-x