Pan-cancer methylation analysis reveals an inverse correlation of tumor immunogenicity with methylation aberrancy

Tumor immunogenicity is driven by various genomic and transcriptomic factors but the association with the overall status of methylation aberrancy is not well established. We analyzed The Cancer Genome Atlas pan-cancer database to investigate whether the overall methylation aberrancy links to the imm...

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Bibliographic Details
Published in:Cancer Immunology, Immunotherapy Immunotherapy, 2021-06, Vol.70 (6), p.1605-1617
Main Authors: Park, Changhee, Jeong, Kyeonghun, Park, Joon-Hyeong, Jung, Sohee, Bae, Jeong Mo, Kim, Kwangsoo, Ock, Chan-Young, Kim, Miso, Keam, Bhumsuk, Kim, Tae Min, Jeon, Yoon Kyung, Lee, Se-Hoon, Lee, Ju-Seog, Kim, Dong-Wan, Kang, Gyeong Hoon, Chung, Doo Hyun, Heo, Dae Seog
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - genetics
Biomarkers, Tumor - immunology
Cancer
Cancer Research
CpG Islands
Cytolytic activity
Cytotoxicity
DNA Methylation
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Genomic instability
Humans
Immune checkpoint inhibitors
Immunogenicity
Immunology
Immunosurveillance
Lymphocytes T
Medicine
Medicine & Public Health
Mutation
Neoplasms - genetics
Neoplasms - immunology
Neoplasms - pathology
Oncology
Original
Original Article
Prognosis
Promoter Regions, Genetic
Survival Rate
Transcriptome
Tumors
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Summary:Tumor immunogenicity is driven by various genomic and transcriptomic factors but the association with the overall status of methylation aberrancy is not well established. We analyzed The Cancer Genome Atlas pan-cancer database to investigate whether the overall methylation aberrancy links to the immune evasion of tumor. We created the definitions of hypermethylation burden, hypomethylation burden and methylation burden to establish the values that represent the degree of methylation aberrancy from human methylation 450 K array data. Both hypermethylation burden and hypomethylation burden significantly correlated with global methylation level as well as methylation subtypes defined in previous literatures. Then we evaluated whether methylation burden correlates with tumor immunogenicity and found that methylation burden showed a significant negative correlation with cytolytic activity score, which represent cytotoxic T cell activity, in pan-cancer (Spearman rho = − 0.37, p  
ISSN:0340-7004
1432-0851
DOI:10.1007/s00262-020-02796-1