Short-term versus usual-term antibiotic treatment for uncomplicated Staphylococcus aureus bacteremia: a systematic review and meta-analysis

Introduction: Uncomplicated Staphylococcus aureus bacteremia remains a leading cause of morbidity and mortality in hospitalized patients. Current guidelines recommend a minimum of 14 days of treatment. Objective: To evaluate the efficacy and safety of short versus usual antibiotic therapy in adults...

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Bibliographic Details
Published in:Therapeutic advances in infectious disease 2024-01, Vol.11
Main Authors: Grillo Perez, Santiago, Diaz-Brochero, Candida, Garzon Herazo, Javier Ricardo, Muñoz Velandia, Oscar Mauricio
Format: Article
Language:English
Subjects:
Systematic Review
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Summary:Introduction: Uncomplicated Staphylococcus aureus bacteremia remains a leading cause of morbidity and mortality in hospitalized patients. Current guidelines recommend a minimum of 14 days of treatment. Objective: To evaluate the efficacy and safety of short versus usual antibiotic therapy in adults with uncomplicated S. aureus bacteremia (SAB). Methods: We developed a search strategy to identify systematic review and meta-analysis of non-randomized studies (NRS), comparing short versus usual or long antibiotic regimens for uncomplicated SAB in MEDLINE, Embase, and the Cochrane Register up to June 2023. The risk of bias was assessed using the ROBINS I tool. The meta-analysis was performed using Review Manager software with a random effect model. Results: Six NRS with a total of 1700 patients were included. No significant differences were found when comparing short versus prolonged antibiotic therapy as defined by the authors for 90-day mortality [odds ratio (OR): 1.09; 95% confidence interval (CI): 0.82–1.46, p: 0.55; I 2  = 0%] or 90-day recurrence or relapse of bacteremia [OR: 0.72; 95% CI: 0.31–1.68, p: 0.45; I 2  = 26%]. Sensitivity analysis showed similar results when comparing a predefined duration of
ISSN:2049-9361
2049-937X
DOI:10.1177/20499361241237615