Closed-loop experiments and brain machine interfaces with multiphoton microscopy

In the field of neuroscience, the importance of constructing closed-loop experimental systems has increased in conjunction with technological advances in measuring and controlling neural activity in live animals. We provide an overview of recent technological advances in the field, focusing on close...

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Bibliographic Details
Published in:Neurophotonics (Print) 2024-07, Vol.11 (3), p.033405-033405
Main Author: Hira, Riichiro
Format: Article
Language:English
Subjects:
Special Section on Understanding of Neural Circuits with Neurophotonics
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Summary:In the field of neuroscience, the importance of constructing closed-loop experimental systems has increased in conjunction with technological advances in measuring and controlling neural activity in live animals. We provide an overview of recent technological advances in the field, focusing on closed-loop experimental systems where multiphoton microscopy-the only method capable of recording and controlling targeted population activity of neurons at a single-cell resolution -works through real-time feedback. Specifically, we present some examples of brain machine interfaces (BMIs) using two-photon calcium imaging and discuss applications of two-photon optogenetic stimulation and adaptive optics to real-time BMIs. We also consider conditions for realizing future optical BMIs at the synaptic level, and their possible roles in understanding the computational principles of the brain.
ISSN:2329-423X
2329-4248
DOI:10.1117/1.NPh.11.3.033405