Proliferation of HIV-1 reservoir cells: The delusion of infinite growth

Proliferation of HIV-1-infected cells contributes to viral persistence despite antiretroviral therapy. A new study by Kufera et al. (https://doi.org/10.1084/jem.20231511) demonstrates that proliferative growth of cells infected with genome-intact HIV-1 is not limitless; rather, these cells seem to b...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of experimental medicine 2024-03, Vol.221 (3)
Main Authors: Lancien, Melanie, Lichterfeld, Mathias
Format: Article
Language:English
Subjects:
CD4-Positive T-Lymphocytes
Cell Proliferation
Delusions
HIV Infections
HIV-1
Humans
Infectious Disease and Host Defense
Insights
Virus Replication
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Proliferation of HIV-1-infected cells contributes to viral persistence despite antiretroviral therapy. A new study by Kufera et al. (https://doi.org/10.1084/jem.20231511) demonstrates that proliferative growth of cells infected with genome-intact HIV-1 is not limitless; rather, these cells seem to be at least partially refractory to TCR stimulation, restricting their ability to proliferate in response to antigenic challenge.
ISSN:0022-1007
1540-9538
1540-9538
DOI:10.1084/jem.20232321