The Effects of Free Breathing on Cerebral Venous Flow: A Real-Time Phase Contrast MRI Study in Healthy Adults

Quantifying the effects of free breathing on cerebral venous flow is crucial for understanding cerebral circulation mechanisms and clinical applications. Unlike conventional cine phase-contrast MRI sequences (CINE-PC), real-time phase-contrast MRI sequences (RT-PC) can provide a continuous beat-to-b...

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Bibliographic Details
Published in:The Journal of neuroscience 2024-01, Vol.44 (3), p.e0965232023-RM-0965-23
Main Authors: Liu, Pan, Monnier, Heimiri, Owashi, Kimi, Constans, Jean-Marc, Capel, Cyrille, Balédent, Olivier
Format: Article
Language:English
Subjects:
Adult
Blood circulation
Blood flow
Blood Flow Velocity
Breathing
Cerebral blood flow
Cerebral Veins - diagnostic imaging
Cerebrovascular Circulation
Cognitive science
Female
Flow velocity
Humans
Jugular vein
Jugular Veins - diagnostic imaging
Life Sciences
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Neuroscience
Phase contrast
Real time
Sinuses
Spatial discrimination
Spatial resolution
Stroke volume
Superior sagittal sinus
Time domain analysis
Veins
Veins & arteries
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Summary:Quantifying the effects of free breathing on cerebral venous flow is crucial for understanding cerebral circulation mechanisms and clinical applications. Unlike conventional cine phase-contrast MRI sequences (CINE-PC), real-time phase-contrast MRI sequences (RT-PC) can provide a continuous beat-to-beat flow signal that makes it possible to quantify the effect of breathing on cerebral venous flow. In this study, we examined 28 healthy human participants, comprising of 14 males and 14 females. Blood flows in the right/left internal jugular veins in the extracranial plane and the superior sagittal sinus (SSS) and straight sinus in the intercranial plane were quantified using CINE-PC and RT-PC. The first objective of this study was to determine the accuracy of RT-PC in quantifying cerebral venous flow, relative to CINE-PC. The second, and main objective, was to quantify the effect of free breathing on cerebral venous flow, using a time-domain multiparameter analysis method. Our results showed that RT-PC can accurately quantify cerebral venous flow with a 2 × 2 mm spatial resolution and 75 ms/image time resolution. The mean flow rate, amplitude, stroke volume, and cardiac period of cerebral veins were significantly higher from the mid-end phase of expiration to the mid-end phase of inspiration. Breathing affected the mean flow rates in the jugular veins more than those in the SSS and straight sinus. Furthermore, the effects of free breathing on the flow rate of the left and right jugular veins were not synchronous. These new findings provide a useful reference for better understanding the mechanisms of cerebral circulation.
ISSN:0270-6474
1529-2401
1529-2401
DOI:10.1523/JNEUROSCI.0965-23.2023