Intravital photoacoustic brain stimulation with high-precision

Neural regulation at high precision vitally contributes to propelling fundamental understanding in the field of neuroscience and providing innovative clinical treatment options. Recently, photoacoustic brain stimulation has emerged as a cutting-edge method for precise neuromodulation and shows great...

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Bibliographic Details
Published in:	Journal of biomedical optics 2024-01, Vol.29 (Suppl 1), p.S11520-S11520
Main Authors:	Wang, Guangxing, Zhou, Yuying, Yu, Chunhui, Yang, Qiong, Chen, Lin, Ling, Shuting, Chen, Pengyu, Xing, Jiwei, Wu, Huiling, Zhao, Qingliang
Format:	Article
Language:	eng
Subjects:	Brain - diagnostic imaging Photoacoustic Techniques - methods Prospective Studies Special Issue Honoring Lihong V. Wang, Pioneer in Biomedical Optics
Online Access:	Get full text
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Summary:	Neural regulation at high precision vitally contributes to propelling fundamental understanding in the field of neuroscience and providing innovative clinical treatment options. Recently, photoacoustic brain stimulation has emerged as a cutting-edge method for precise neuromodulation and shows great potential for clinical application. The goal of this perspective is to outline the advancements in photoacoustic brain stimulation in recent years. And, we also provide an outlook delineating several prospective paths through which this burgeoning approach may be substantively refined for augmented capability and wider implementations. First, the mechanisms of photoacoustic generation as well as the potential mechanisms of photoacoustic brain stimulation are provided and discussed. Then, the state-of-the-art achievements corresponding to this technology are reviewed. Finally, future directions for photoacoustic technology in neuromodulation are provided. Intensive research endeavors have prompted substantial advancements in photoacoustic brain stimulation, illuminating the unique advantages of this modality for noninvasive and high-precision neuromodulation via a nongenetic way. It is envisaged that further technology optimization and randomized prospective clinical trials will enable a wide acceptance of photoacoustic brain stimulation in clinical practice. The innovative practice of photoacoustic technology serves as a multifaceted neuromodulation approach, possessing noninvasive, high-accuracy, and nongenetic characteristics. It has a great potential that could considerably enhance not only the fundamental underpinnings of neuroscience research but also its practical implementations in a clinical setting.
ISSN:	1083-3668 1560-2281