Neutrophil Lymphocyte Ratio as a Predictor of Stroke Severity in Type 2 Diabetes Mellitus: A Single-Center Study

Type 2 diabetes mellitus (T2DM) is associated with various microvascular and macrovascular complications. Stroke, being a vascular complication, is associated with severe morbidity and mortality. Neutrophil lymphocyte ratio (NLR), a crude, inexpensive, and rather easily available modality to detect...

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Published in:Curēus (Palo Alto, CA) CA), 2024-01, Vol.16 (1), p.e51841-e51841
Main Authors: Singh, Karan Pal, Singh, Ramandeep, Singh, Tanveer, Kaur, Sukhmandeep, Mittal, Tinish, Goyal, Meena, Inban, Pugazhendi, Musiime, Agaba Barnett James, Haseeb, Madiha D, Khan, Aadil
Format: Article
Language:English
Subjects:
Body mass index
Data collection
Diabetes
Hematology
Hemoglobin
High density lipoprotein
Hyperglycemia
Infectious Disease
Internal Medicine
Ischemia
Leukocytes
Lipids
Lymphocytes
Mann-Whitney U test
Medicine
Metabolism
Neurology
Neutrophils
Nonparametric statistics
Stroke
Variables
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Summary:Type 2 diabetes mellitus (T2DM) is associated with various microvascular and macrovascular complications. Stroke, being a vascular complication, is associated with severe morbidity and mortality. Neutrophil lymphocyte ratio (NLR), a crude, inexpensive, and rather easily available modality to detect inflammation, has been utilized to find the extent of inflammation in type 2 diabetes mellitus patients. In this study, we find the effect of hemoglobin A1c (HbA1c) on NLR and the effect of NLR on stroke severity index. This study aims to determine the use of the NLR in predicting stroke severity in a type 2 diabetes mellitus patient. This study is an observational cross-sectional study. A total of 400 patients were enrolled, all of whom had type 2 diabetes mellitus, with 200 of them diagnosed with an ischemic stroke. The National Institute of Health stroke scale (NIHSS) was used to standardize stroke severity and NLR was calculated from differential counts. The mean NLR for patients with type 2 diabetes mellitus was 3.87 ± 0.76 (mean ± SD), while for those with type 2 diabetes mellitus and stroke, it was 7.89 ± 1.29 (mean ± SD), with a statistically significant p-value < 0.001. Additionally, for every 1 unit increase in HbA1c, the NLR increased by 0.38 in type 2 diabetes mellitus patients and 0.86 in type 2 diabetes mellitus patients with stroke. Furthermore, each 1-unit increase in NLR corresponded to a rise of 0.80 in the stroke severity index. The study shows a significant correlation between NLR in type 2 diabetes mellitus patients and stroke in type 2 diabetes mellitus patients. Also, it shows the significance of NLR in predicting stroke severity.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.51841