Activation of the Drosophila NF-κB factor Relish by rapid endoproteolytic cleavage

The Rel/NF‐κB transcription factor Relish plays a key role in the humoral immune response in Drosophila. We now find that activation of this innate immune response is preceded by rapid proteolytic cleavage of Relish into two parts. An N‐terminal fragment, containing the DNA‐binding Rel homology doma...

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Published in:EMBO reports 2000-10, Vol.1 (4), p.347-352
Main Authors: Stöven, Svenja, Ando, Istvan, Kadalayil, Latha, Engström, Ylva, Hultmark, Dan
Format: Article
Language:English
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Scientific Reports
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Summary:The Rel/NF‐κB transcription factor Relish plays a key role in the humoral immune response in Drosophila. We now find that activation of this innate immune response is preceded by rapid proteolytic cleavage of Relish into two parts. An N‐terminal fragment, containing the DNA‐binding Rel homology domain, translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably to the promoters of other antimicrobial peptide genes. The C‐terminal IκB‐like fragment remains in the cytoplasm. This endoproteolytic cleavage does not involve the proteasome, requires the DREDD caspase, and is different from previously described mechanisms for Rel factor activation.
ISSN:1469-221X
1469-3178
DOI:10.1093/embo-reports/kvd072