Unraveling the complex dynamics of signaling molecules in cellular signal transduction

Signaling molecules in cellular responses to foreign stimuli are described as static up- or down-concentration changes during signal transduction. This is because analytical methods for transducing molecules are much slower than the signaling events. In this study, we develop a dynamic cell model an...

Full description

Saved in:
Bibliographic Details
Published in:PNAS nexus 2024-01, Vol.3 (1), p.pgae020-pgae020
Main Authors: Wang, Shenqing, Zhang, Yi, Zhang, Liangwei, Huang, Yan, Zhang, Jie, Zhang, Kena, Huang, Yujie, Su, Gaoxing, Chen, Lingxin, Yan, Bing
Format: Article
Language:English
Subjects:
Analysis
Biological, Health, and Medical Sciences
Cellular signal transduction
Reactive oxygen species
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Signaling molecules in cellular responses to foreign stimuli are described as static up- or down-concentration changes during signal transduction. This is because analytical methods for transducing molecules are much slower than the signaling events. In this study, we develop a dynamic cell model and reveal the temporal regulation of signal transduction events in response to reactive oxygen species (ROS). The model contained a set of 10 batches of redox-modified cells that mimic the temporal ROS accumulation events. Validating this dynamic cell model, we discover that cells survive early ROS attacks by activating the Nrf2/polysulfide/p62/CDK1 pathway. Nearly all signaling molecules exhibit time-dependent V-shape or inverse V-shape activation/feedback regulation dynamics in response to ROS accumulation. The results show that the dynamic cell model approach is invaluable for revealing complex signal intensity- and time-dependent cell signaling events.
ISSN:2752-6542
2752-6542
DOI:10.1093/pnasnexus/pgae020