Ipsilateral hemigland prostate biopsy may underestimate cancer burden in patients with unilateral mpMRI-visible lesions

Purpose To evaluate the cancer detection rates of reduced-core biopsy schemes in patients with unilateral mpMRI-visible intraprostatic lesions and to analyze the contribution of systematic biopsy cores in clinically significant prostate cancer (csPCa) detection. Methods 212 patients with mpMRI-visib...

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Bibliographic Details
Published in:Abdominal imaging 2023-03, Vol.48 (3), p.1079-1089
Main Authors: Phelps, Tim E., Yilmaz, Enis C., Harmon, Stephanie A., Belue, Mason J., Shih, Joanna H., Garcia, Charisse, Hazen, Lindsey A., Toubaji, Antoun, Merino, Maria J., Gurram, Sandeep, Choyke, Peter L., Wood, Bradford J., Pinto, Peter A., Turkbey, Baris
Format: Article
Language:English
Subjects:
Biopsy
Cancer
Clinical significance
Confidence intervals
Gastroenterology
Hepatology
Humans
Image-Guided Biopsy
Imaging
Lesions
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Multiparametric Magnetic Resonance Imaging
Pelvis
Prostate
Prostate - pathology
Prostate cancer
Prostatic Neoplasms - pathology
Radiology
Regression analysis
Statistical analysis
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Summary:Purpose To evaluate the cancer detection rates of reduced-core biopsy schemes in patients with unilateral mpMRI-visible intraprostatic lesions and to analyze the contribution of systematic biopsy cores in clinically significant prostate cancer (csPCa) detection. Methods 212 patients with mpMRI-visible unilateral intraprostatic lesions undergoing MRI/TRUS fusion-guided targeted biopsy (TBx) and systematic biopsy (SBx) were included. Cancer detection rates of TBx + SBx, as determined by highest Gleason Grade Group (GG), were compared to 3 reduced-core biopsy schemes: TBx alone, TBx + ipsilateral systematic biopsy (IBx; MRI-positive hemigland), and TBx + contralateral systematic biopsy (CBx; MRI-negative hemigland). Patient-level and biopsy core-level data were analyzed using descriptive statistics with confidence intervals. Univariable and multivariable logistic regression analysis was conducted to identify predictors of csPCa (≥ GG2) detected in MRI-negative hemiglands at p 
ISSN:2366-0058
2366-004X
2366-0058
DOI:10.1007/s00261-022-03775-z