The Contribution of DNA Ligase 4 Polymorphisms to Colorectal Cancer

While numerous biomarkers associated with genetic susceptibility to colorectal cancer (CRC) have been identified and validated through epidemiological studies, the specific influence of DNA ligase 4 (Lig4) genotypes remains unexplored. This study aimed to elucidate the hitherto unexamined relationsh...

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Bibliographic Details
Published in:In vivo (Athens) 2024-01, Vol.38 (1), p.127-133
Main Authors: Deng, Yang, Ke, Tao-Wei, Yueh, Te-Cheng, Chin, Yu-Ting, Wang, Yun-Chi, Hung, Yi-Chih, Mong, Mei-Chin, Yang, Ya-Chen, Wu, Wen-Tzu, Chang, Wen-Shin, Gu, Jian, Bau, DA-Tian, Tsai, Chia-Wen
Format: Article
Language:English
Subjects:
Case-Control Studies
Colorectal Neoplasms - epidemiology
Colorectal Neoplasms - genetics
Genetic Predisposition to Disease
Genotype
Humans
Polymorphism, Single Nucleotide
Risk
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Summary:While numerous biomarkers associated with genetic susceptibility to colorectal cancer (CRC) have been identified and validated through epidemiological studies, the specific influence of DNA ligase 4 (Lig4) genotypes remains unexplored. This study aimed to elucidate the hitherto unexamined relationship between Lig4 genotypes and CRC risk. The genotypes of Lig4 rs1805388 were determined applying the polymerase chain reaction-restriction fragment length polymorphism methodology. The potential association between these genotypes and CRC risk was assessed in a Taiwanese population comprising 362 CRC cases and an equal number of age- and sex-matched controls. In the genotypic analysis, the distribution of CC, CT, and TT genotypes for Lig4 rs1805388 among CRC cases was 54.7%, 38.1%, and 7.2%, respectively. This distribution was not significantly different from the controls, which exhibited genotypic frequencies of 57.2%, 36.7%, and 6.1%, respectively (p for trend=0.7314). Analysis of allelic distribution indicated that individuals carrying the T allele of Lig4 rs1805388 displayed a slightly elevated CRC risk compared to those carrying the C allele (odds ratio=1.10, 95% confidence interval=0.87-1.39, p=0.4685). The variant genotypes of Lig4 rs1805388 may not serve as predictive markers for CRC risk in the Taiwanese population.
ISSN:0258-851X
1791-7549
DOI:10.21873/invivo.13419