Comparison of the efficacy of 5% versus 8% acetic acid concentrations for detecting premalignant and malignant lesions in colposcopy

Although preventable; cervical cancer remains a significant cause of morbidity and mortality worldwide, especially in developing countries; thus, early diagnosis and treatment are essential to prevent its development into invasive cancer. Based on the screening results, diagnostic colposcopy was per...

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Bibliographic Details
Published in:Medicine (Baltimore) 2023-12, Vol.102 (50), p.e36341-e36341
Main Authors: Yilmaz, Alpay, Gulbahar, Aysegul, Sen, Serhat
Format: Article
Language:English
Subjects:
Acetic Acid
Colposcopy
Early Detection of Cancer
Female
Humans
Observational Study
Papillomaviridae - genetics
Papillomavirus Infections - diagnosis
Precancerous Conditions - diagnosis
Pregnancy
Retrospective Studies
Uterine Cervical Dysplasia
Uterine Cervical Neoplasms - pathology
Vaginal Smears
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Summary:Although preventable; cervical cancer remains a significant cause of morbidity and mortality worldwide, especially in developing countries; thus, early diagnosis and treatment are essential to prevent its development into invasive cancer. Based on the screening results, diagnostic colposcopy was performed to evaluate women with abnormal Papinocalaou test results, high-risk human papillomavirus DNA positivity, or suspected cervical cancer. Therefore, this study aimed to determine the optimal acetic acid concentration (5% or 8%) for detecting cervical precancerous/cancerous lesions during colposcopy evaluation. This study included 607 patients admitted to our obstetrics and gynecology clinic. The medical records of the patients were obtained from the colposcopy registry in the hospital information system and retrospectively analyzed. The cases were divided into 2 groups according to the acetic acid concentrations (5% and 8%) used during colposcopy and examined. The duration of acetic acid application was 2 to 4 minutes. The probability of developing ≥ CIN2 was low in patients with negative for intraepithelial lesion or malignancy smear results in both groups, but increased in the high-grade squamous intraepithelial lesions/atypical squamous cells group with the 8% acetic acid concentration (P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000036341