Altered White Matter Connectivity Associated with Intergyral Brain Disorganization in Hemiplegic Cerebral Palsy

•Damaged sensorimotor fibers disorganize intergyral connections in children with hemiplegic cerebral palsy.•Damage in projection fibers disturbs balance of short- and long-range connections in hemiplegic cerebral palsy.•Long- and middle-range association fibers are more vulnerable in the affected he...

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Bibliographic Details
Published in:Neuroscience 2019-02, Vol.399, p.146-160
Main Authors: Papadelis, Christos, Ahtam, Banu, Feldman, Henry A., AlHilani, Michel, Tamilia, Eleonora, Nimec, Donna, Snyder, Brian, Ellen Grant, P., Im, Kiho
Format: Article
Language:English
Subjects:
Adolescent
Brain - diagnostic imaging
central nervous system injury: imaging
cerebral palsy
Cerebral Palsy - complications
Cerebral Palsy - diagnostic imaging
Child
Cohort Studies
cortical plasticity
Diffusion Tensor Imaging
Female
Hemiplegia - complications
Hemiplegia - diagnostic imaging
Humans
Male
Neural Pathways - diagnostic imaging
plasticity
sensory systems
spasticity
White Matter - diagnostic imaging
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Summary:•Damaged sensorimotor fibers disorganize intergyral connections in children with hemiplegic cerebral palsy.•Damage in projection fibers disturbs balance of short- and long-range connections in hemiplegic cerebral palsy.•Long- and middle-range association fibers are more vulnerable in the affected hemisphere of hemiplegic cerebral palsy.•Sensory, motor, and association fibers have different profiles of diffusion changes in hemiplegic cerebral palsy. Despite extensive literature showing damages in the sensorimotor projection fibers of children with hemiplegic cerebral palsy (HCP), little is known about how these damages affect the global brain network. In this study, we assess the relationship between the structural integrity of sensorimotor projection fibers and the integrity of intergyral association white matter connections in children with HCP. Diffusion tensor imaging was performed in 10 children with HCP and 16 typically developing children. We estimated the regional and global white-matter connectivity using a region-of-interest (ROI)-based approach and a whole-brain gyrus-based parcellation method. Using the ROI-based approach, we tracked the spinothalamic (STh), thalamocortical (ThC), corticospinal (CST), and sensorimotor U- (SMU) fibers. Using the whole-brain parcellation method, we tracked the short-, middle-, and long-range association fibers. We observed for the more affected hemisphere of children with HCP: (i) an increase in axial diffusivity (AD), mean diffusivity (MD), and radial diffusivity (RD) for the STh and ThC fibers; (ii) a decrease in fractional anisotropy (FA) and an increase in MD and RD for the CST and SMU fibers; in (iii) a decrease in FA and an increase in AD, MD, and RD for the middle- and long-range association fibers; and (iv) an association between the integrity of sensorimotor projection and intergyral association fibers. Our findings indicate that altered structural integrity of the sensorimotor projection fibers disorganizes the intergyral association white matter connections among local and distant regions in children with HCP.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2018.12.028